A Comparative Analysis of Constitutive Promoters Located in Adeno-Associated Viral Vectors
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منابع مشابه
A Comparative Analysis of Constitutive Promoters Located in Adeno-Associated Viral Vectors
The properties of constitutive promoters within adeno-associated viral (AAV) vectors have not yet been fully characterized. In this study, AAV vectors, in which enhanced GFP expression was directed by one of the six constitutive promoters (human β-actin, human elongation factor-1α, chicken β-actin combined with cytomegalovirus early enhancer, cytomegalovirus (CMV), simian virus 40, and herpes s...
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Duchenne muscular dystrophy (BMD) is an inherited X-link disease. The incidence of this muscle-wasting disease is 1:5000 male live births. Mutation in the gene coding for dystrophin is the main cause of BMD. Most cases of this disease succumb to respiratory and cardiac failure in 3rd to 4th decades. The slow progression of BMD and recent achievement of gene therapies make it as an appropriate c...
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Adeno-associated virus (AAV) is a non-pathogenic humanDNAviruswith a unique profile of biological properties that have been of interest to molecular virologists for many years (Berns, 1990; Carter, 1990; Carter et al., 1990). Recently,AAV has also attracted interest as a vector for gene transfer (Carter, 1992; Flotte, 1993a; Hermonat andMuzyczka, 1984; Tratschin et al., 1984). In a general sens...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0106472